PharmBioTec gGmbH is specialized in the development of innovative and customized formulations for a wide range of pharmaceutical applications. Our portfolio includes inhalation systems, creams, nasal sprays, and modern delivery systems such as innovative nanocarriers. We combine scientific expertise with practice-orientated development to create the optimal dosage form for every active ingredient.

Thanks to our many years of experience collaborating with industry and research partners, we are able to develop precisely tailored formulation strategies in the early preclinical development phase. Our goal is to make the best possible use of your active ingredient’s properties while addressing potential challenges early on. This includes, in particular, limiting factors such as low solubility or restricted permeability, for which we develop targeted solutions.

A particular focus of our work is on the development and application of alternative testing systems to avoid costly and ethically questionable animal testing. Our formulations are therefore tested on specially established in vitro and ex vivo models. Depending on the research question, we use, for example, lung or intestinal cell culture models, skin models, or dental test systems. This allows us to make reliable statements about the efficacy, tolerability, and performance of your formulation at an early stage.

As preclinical development progresses, we also offer comprehensive contract analytical services. These include, among other things, HPLC and HPLC-MS analyses, absorption measurements, and the determination of physicochemical properties such as the melting point of proteins. Our services range from the development and validation of custom analytical methods to the execution of regular measurement series, for example as part of stability studies.

We would be happy to provide you with a customized quote tailored precisely to your requirements — from the initial idea through method development to long-term analytical support for your project.

To name a few examples, we offer the following as standard upon request:

With focus on oral application:

Inflammation model intestine to investigate efficacy and safety.

Investigation of permeation on Caco-2 cells for evaluation of transport properties or assessment of bioequivalence

Focusing on nasal or pulmonary application:

Examination of permeation on Calu-3 cells for evaluation of transport properties or assessment of bioequivalence.

Testing of intranasal formulations and devices using a 3D nasal model

Measurement of mucoadhesion to support bioequivalence studies or formulation development

Evaluation of excipients for pulmonary use using SAFE

Determination of MMAD for the evaluation of aerosol properties

With focus on dermal applications

Skin permeation to evaluate new formulations and to study bioequivalence