Welcome to PharmBioTec Research & Development GmbH
PharmBioTec Research & Development GmbH is a company certified according to §14 AMG GMP and specialized in contract research. It provides high-quality services
in the fields of pharmaceutical analytics, synthesis, and research & development.
PharmBioTec was founded in 2010 as a subsidiary of Saarland University by 3 professors of pharmacy (Hartmann, Müller & Lehr) and works in close cooperation with the Institute of Pharmaceutical and Medical Chemistry, the working group Biopharmacy & Pharmaceutical Technology and the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS). PharmBioTec can draw on several decades of experience in the design, synthesis, biological testing, formulation and analysis of new drugs.
At the beginning of 2019, PharmBioTec was released into private ownership as a non-profit company in order to better ensure the knowledge transfer of current research to industrial applications.
A major goal of PharmBioTec Research & Development GmbHis to replace animal experiments in the preclinical development phase of drugs. For this purpose, various models of biological barriers are offered that provide predictions on the efficacy and safety of new developments. The creation of new models to pursue this goal is constantly progressing. Examples include the model of the intestine (healthy/inflammatory), the skin or the lung in combination with novel deposition systems such as the VITROCELL® Powder Chamber. Classical pharmaceutical formulations and novel nanocarrier systems are developed within the scope of contract research and enable targeted drug release. In addition, they are biodegradable.
The following methods are used successfully in the analysis and quality control of active ingredients, excipients and finished drugs: HPLC-UV, HPLC-DAD, HPLC-MS, HPLC-hrMS, HPLC-MS/MS, UV, IR, CE-SDS, CE-UV, CE-DAD, CE-MS, ultra-high resolution mass spectrometry, determination of moisture by Karl-Fischer (volumetric, coulometric, furnace technology). In addition, we perform rheological characterizations as part of the formulation development of semi-solid and solid formulations (oscillating and rotating).
In addition, we develop and synthesize substance libraries for hit-to-lead and lead optimization. Our array approach is based on automated parallel synthesis and combinatorial chemistry as well as many years of knowledge in medical and pharmaceutical chemistry. We have a number of synthesis robots that can individually perform up to 50 reactions including automatic processing and purification. The substance libraries and acquired compounds can be examined for their physicochemical properties as well as for their binding to different proteins, e.g. your target. In the field of protein binding we have many years of experience with SPR spectroscopy.
Another important field of analytics is the detection and quantification of small molecules in different biological matrices. With our HPLC-MS/MS and HPLC-hrMS methods we are able to detect and quantify the smallest amounts of substances, even in the fg range, as required in stability studies and PK studies.
PharmBioTec Research & Development GmbH offers a range of high-quality services at various stages of the development process of
new active ingredients and formulations...
As a non-profit company, PharmBioTec Research & Development GmbH is active in the field of basic research...
Since 2015 we are certified according to §14 AMG GMP and offer high-quality analytical services and quality control